Casebook

Structures read as cases.

Structures read as cases: the target, the pocket, the series and the paper, with every entry Marc deposited or co-authored.

Marc's public structures by release year

79 entries, coloured by role

Role comes from the RCSB depositor and primary-citation searches and Marc's curated list. Private Incyte and Pfizer structures are not counted.

Cases and commentary

17 articles

8 Mar 2026 · 1 min read Discovery of an Orally Bioavailable KRAS G12D Inhibitor Discovery of an Orally Bioavailable KRAS G12D Inhibitor Description: This structure represents a major breakthrough in targeted oncology, revealing the binding mode of IN… 8 Mar 2026 · 1 min read Discovery of an Orally Bioavailable KRAS G12D Inhibitor_2 Discovery of an Orally Bioavailable KRAS G12D Inhibitor Description: A companion structure to 9E5D, this 1.35 Å resolution crystal captures KRAS G12D in complex with Comp… 8 Mar 2026 · 1 min read Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2 Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2 Description: This structure reveals the molecular basis of u… 8 Mar 2026 · 1 min read FGFR2 Kinase Domain in Complex with a Pyrazolo[1,5-a]pyrimidine Analog (Compound 29) FGFR2 Kinase Domain in Complex with a Pyrazolo[1,5-a]pyrimidine Analog (Compound 29) Description: This structure elucidates the binding mode of Compound 29, a potent and … 10 Sep 2025 · 3 min read JAK2-V617F and the Evolution of Targeted Therapy: Precision Medicine Transforms Myeloproliferative Neoplasm Treatment JAK2-V617F and the Evolution of Targeted Therapy: Precision Medicine Transforms Myeloproliferative Neoplasm Treatment https://marcdeller.com/wp-content/uploads/2025/09/v6… 8 Sep 2025 · 7 min read My Work Driving Innovation in Precision Oncology Through Structure-Based Drug Design My Work Driving Innovation in Precision Oncology Through Structure-Based Drug Design 6+ FDA IND filings across oncology, immunology, and virology, anchored by structure-b… 12 Dec 2025 · 5 min read Molecular Architecture of GLP-1 Receptor Drug Binding Reveals Dynamic Activation Mechanisms Molecular Architecture of GLP-1 Receptor Drug Binding Reveals Dynamic Activation Mechanisms Evolving cryo-EM structural approaches for GPCR drug discovery Deep Pocket Arc… 18 Oct 2025 · 4 min read TYK2 Biology: How Deep Mutational Scanning Reveals New Therapeutic Frontiers TYK2 Biology: How Deep Mutational Scanning Reveals New Therapeutic Frontiers Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and … 6 Dec 2025 · 2 min read Tuning the Signal: Rational Design of G Protein Selectivity Tuning the Signal: Rational Design of G Protein Selectivity Molecular ‘glues’ and ‘bumpers’ on receptors can bias signalling inside the cell Molecular Bumpers: Allosteric… 15 Oct 2025 · 7 min read The Unsung Hero: How a Single Chlorine Atom Transforms Drug Discovery The Unsung Hero: How a Single Chlorine Atom Transforms Drug Discovery “Magic Chloro”: Profound Effects of the Chlorine Atom in Drug Discovery Potency Amplification: Singl… 15 Sep 2025 · 7 min read Unlocking Molecular Potential: The Evolution of Topliss Tree and Bioisosteric Strategies in Modern Drug Discovery Unlocking Molecular Potential: The Evolution of Topliss Tree and Bioisosteric Strategies in Modern Drug Discovery Systematic Optimization Foundation: The Topliss tree met… 22 Aug 2025 · 2 min read The LockTac Revolution: Binding the Future of Therapeutics The LockTac Revolution: Binding the Future of Therapeutics LOCKTACs stabilize, rather than disrupt, natural biomolecular interactions. They offer therapeutic avenues for … 13 Oct 2025 · 5 min read The $40 Billion Revolution: How Bispecific Antibodies Are Transforming Cancer Care The $40 Billion Revolution: How Bispecific Antibodies Are Transforming Cancer Care The $40 Billion Race: Bispecific Antibodies Are Redefining Cancer Therapy Market Transf… 27 Aug 2025 · 4 min read Nanobodies: Revolutionizing Molecular Medicine Through Nature’s Smallest Antibodies Nanobodies: Revolutionizing Molecular Medicine Through Nature’s Smallest Antibodies Revolutionary Architecture: Single-domain structure achieves full antigen binding in j… 20 Aug 2025 · 3 min read Shedding Light on the Shadows: The Untapped Potential of the Dark Kinome Shedding Light on the Shadows: The Untapped Potential of the Dark Kinome The dark kinome comprises a significant portion of human kinases with poorly understood functions… 13 Oct 2025 · 3 min read Precision Timing of Cytokine Signals through Facilitated Dissociation Precision Timing of Cytokine Signals through Facilitated Dissociation Design of facilitated dissociation enables timing of cytokine signalling Molecular Timer: Engineered… 22 Aug 2025 · 2 min read The Shape-Shifting World of Intrinsically Disordered Region Binding Proteins The Shape-Shifting World of Intrinsically Disordered Region Binding Proteins IDRs lack stable structures, making them historically difficult to target. New computational …

From Marc's papers

12 articles

2 Jun 2026 · 3 min read 2026 – Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases … 11 Aug 2025 · 4 min read 2025 – Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor Link to Paper Prevalence Impact: KRAS G12D represents the most common KRAS mutation, affecting 29% of … 11 Aug 2025 · 4 min read 2024 – Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective CDK2 Inhibitors Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective CDK2 Inhibitors Link to Paper Selective Targeting: (4-Pyrazolyl)-2-aminopyrimidines achieve unpreced… 11 Aug 2025 · 3 min read 2022 – Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2/3 Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2/3 Link to Paper Potent Dual Inhibition: Compound 29 retains low-nanomolar potency ag… 11 Aug 2025 · 3 min read 2018 – Structure–function analysis of the extended conformation of a polyketide synthase module Structure–function analysis of the extended conformation of a polyketide synthase module Link to Paper Extended Architecture: Antibody stabilization reveals a linear doma… 11 Aug 2025 · 3 min read 2017 – The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase Link to Paper Sphere Stabilization: H161 and Q167 form a hydrogen-bond network that… 2 Sep 2025 · 5 min read 2015 – Crystal structure of a two-subunit TrkA octameric gating ring assembly Crystal structure of a two-subunit TrkA octameric gating ring assembly Link to Paper Ancient Architecture Revealed: The two-subunit TrkA system represents an evolutionary… 7 Sep 2025 · 5 min read 2012 – Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33 Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33 Link to Paper Dual Recognition Modes: Two distinct antibod… 11 Aug 2025 · 4 min read 2013 – Crystal structure of a soluble cleaved HIV-1 envelope trimer Crystal structure of a soluble cleaved HIV-1 envelope trimer Link to Paper Structural Architecture: The BG505 SOSIP.664 crystal structure reveals the native-like trimeric… 11 Aug 2025 · 6 min read 2013 – Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Link to Paper Multi-Modal Recognition: The Asn332 supersite uniquely accom… 11 Aug 2025 · 5 min read 2016 – Key gp120 glycans pose roadblocks to the rapid development of VRC01-class antibodies in an HIV-1- infected Chinese donor Key gp120 glycans pose roadblocks to the rapid development of VRC01-class antibodies in an HIV-1-infected Chinese donor Link to Paper Glycan Barrier Mechanisms: The N276 … 11 Aug 2025 · 4 min read 2017 – Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design Link to Paper MPER…

PETase and enzyme engineering

12 articles

15 Aug 2025 · 2 min read Plastic-Eating Enzymes Decoded—PETase’s Structure and Mutation Map Plastic-Eating Enzymes Decoded—PETase’s Structure and Mutation Map PETase’s catalytic triad and binding pocket facilitate PET breakdown. Strategic mutations radically boo… 15 Nov 2025 · 8 min read Decoding the Molecular Machinery Behind Plastic Degradation Decoding the Molecular Machinery Behind Plastic Degradation Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation Catalytic Triad Archit… 5 Nov 2025 · 8 min read Engineering Evolution: How FAST-PETase and Other Variants Are Transforming Plastic Biodegradation Engineering Evolution: How FAST-PETase and Other Variants Are Transforming Plastic Biodegradation FAST-PETase: Machine learning-aided engineering of hydrolases for PET de… 5 Nov 2025 · 6 min read HGMP01 and FAST-PETase: Decoding Two Paths to Plastic Degradation – Engineered versus Natural PETase Enzymes HGMP01 and FAST-PETase: Decoding Two Paths to Plastic Degradation – Engineered versus Natural PETase Enzymes Machine learning-aided engineering of hydrolases for PET depo… 4 Nov 2025 · 6 min read HGMP01 and other Hidden Guardians: How the Human Gut Fights Back Against Plastic Pollution HGMP01 and other Hidden Guardians: How the Human Gut Fights Back Against Plastic Pollution Identification of a PET hydrolytic enzyme from the human gut microbiome unveils… 15 Aug 2025 · 1 min read The Enzyme Toolbox—Alternatives to PETase for Microplastic Breakdown The Enzyme Toolbox—Alternatives to PETase for Microplastic Breakdown Cutinases, MHETases, carboxylesterases, and lipases expand substrate scope. Fusion proteins (CBMs) an… 15 Aug 2025 · 1 min read Engineered Enzymes—Design for Safe, Targeted Microplastic Therapeutics Engineered Enzymes—Design for Safe, Targeted Microplastic Therapeutics Enzyme engineering uses mutations, fusion domains, and glycosylation for optimal PETase variants. D… 15 Aug 2025 · 1 min read PETase Enzyme Therapy—A New Frontier in Medical Microplastic Removal PETase Enzyme Therapy—A New Frontier in Medical Microplastic Removal PETase variants efficiently degrade PET microplastics at human body temperature. Enzyme therapy with … 20 Aug 2025 · 5 min read Revolutionary AI Tool XenoBug Transforms Environmental Pollution Control Through Predictive Enzyme Discovery Revolutionary AI Tool XenoBug Transforms Environmental Pollution Control Through Predictive Enzyme Discovery Revolutionary AI Platform: XenoBug uses machine learning to p… 7 Nov 2025 · 8 min read Unlocking the Power of Protein Engineering: FDA-Approved Enzyme Therapies Transform Rare Disease Treatment Unlocking the Power of Protein Engineering: FDA-Approved Enzyme Therapies Transform Rare Disease Treatment The past, present, and future of enzyme-based therapies Glycoen… 14 Apr 2026 · 3 min read PETase: Nature’s Solution to a Human-Made Problem PETase: Nature’s Solution to a Human-Made Problem PDB-101: Molecule of the Month: Plastic-eating Enzymes Molecule of the Month Elora Therapeutics Bacterial origin: Ideone… 18 Apr 2026 · 6 min read An Enzyme That Eats Plastic — Inside Your Blood An Enzyme That Eats Plastic — Inside Your Blood Data digitized from original research article for display, please refer to original article below for actual data Degradat…

Degraders and modalities

3 articles

13 Aug 2025 · 2 min read Hitting the Delete Button on Disease: The Rise of Targeted Protein Degraders Hitting the Delete Button on Disease: The Rise of Targeted Protein Degraders Targeted Protein Degraders (TPDs) offer a revolutionary way to eliminate disease-causing prot… 13 Aug 2025 · 2 min read Beyond Inhibition: The Rise of Conditional Degraders for Safer Medicines Beyond Inhibition: The Rise of Conditional Degraders for Safer Medicines Conditional degraders like RIPTACs and TriTACs are a next-generation TPD technology designed for … 13 Aug 2025 · 3 min read Beyond the Cell: The New Frontier of Extracellular Protein Degradation Beyond the Cell: The New Frontier of Extracellular Protein Degradation LYTAC Platform: Lycia Therapeutics First FDA-approved PROTAC: Vepdegestrant validates targeted prot…

Structures from the bench

19 articles

Structures from the bench

79 entries

Role Year Method Organism

Entry	Title	Role	Method	Resolution	Released
13GK	CDK2 in complex with INCB125496 Homo sapiens	Marc is an author on the primary citation	X-ray	1.44 Å	30 Sep 2026
10PJ	JAK2 kinase (JH1 domain) in complex with povorcitinib Homo sapiens	Marc is an author on the primary citation	X-ray	1.59 Å	10 Jun 2026
10PI	JAK1 kinase (JH1 domain) in complex with povorcitinib Homo sapiens	Marc is an author on the primary citation	X-ray	1.54 Å	10 Jun 2026
9E5F	Discovery of an Orally Bioavailable KRAS G12D Inhibitor Homo sapiens	Deposited by Marc and an author on the primary citation	X-ray	1.35 Å	22 Jan 2025
9E5D	Discovery of an Orally Biovailable KRAS G12D Inhibitor Homo sapiens	Deposited by Marc and an author on the primary citation	X-ray	1.36 Å	22 Jan 2025
8UV0	Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2 Homo sapiens	Deposited by Marc and an author on the primary citation	X-ray	1.55 Å	14 Feb 2024
8E1X	FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29) Homo sapiens	Deposited by Marc and an author on the primary citation	X-ray	2.68 Å	23 Nov 2022
6OFO	Crystal structure of split green fluorescent protein (GFP); s10 circular permutant (194-195) Aequorea victoria	Deposited by Marc	X-ray	2.60 Å	10 Jul 2019
6C9U	Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) Homo sapiens; Saccharopolyspora erythraea	Marc is an author on the primary citation	X-ray	2.09 Å	23 May 2018
5UFV	Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3*) Thermothelomyces thermophilus ATCC 42464	Deposited by Marc and an author on the primary citation	X-ray	2.45 Å	15 Mar 2017
5TFW	Crystal structure of 10E8 Fab light chain mutant2 against the MPER region of the HIV-1 Env, in complex with T117v2 epitope scaffold Homo sapiens; synthetic construct	Marc is an author on the primary citation	X-ray	2.17 Å	8 Mar 2017
5T85	Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 and phosphatidylglycerol (06:0 PG) Homo sapiens; synthetic construct	Marc is an author on the primary citation	X-ray	2.37 Å	8 Mar 2017
5T80	Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 and phosphatidic acid (06:0 PA) Homo sapiens; synthetic construct	Marc is an author on the primary citation	X-ray	2.62 Å	8 Mar 2017
5T6L	Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 Homo sapiens; synthetic construct	Marc is an author on the primary citation	X-ray	2.10 Å	8 Mar 2017
5T5B	CRYSTAL STRUCTURE OF THE COMPLEX OF 10E8 FAB LIGHT CHAIN MUTANT5 AND T117V2 HIV-1 MPER SCAFFOLD Homo sapiens; synthetic construct	Marc is an author on the primary citation	X-ray	2.07 Å	8 Mar 2017
5T29	Crystal structure of 10E8 Fab light chain mutant3, against the MPER region of the HIV-1 Env, in complex with the MPER epitope scaffold T117v2 Homo sapiens; synthetic construct	Marc is an author on the primary citation	X-ray	2.03 Å	8 Mar 2017
5SY8	Crystal structure of the complex of 10E8 Fab light chain mutant1 and T117v2 HIV-1 MPER scaffold Homo sapiens; synthetic construct	Marc is an author on the primary citation	X-ray	1.62 Å	8 Mar 2017
5CD5	Crystal structure of an immature VRC01-class antibody DRVIA7 from a Chinese donor bound to clade A/E HIV-1 gp120 core Homo sapiens; Human immunodeficiency virus 1	Marc is an author on the primary citation	X-ray	3.40 Å	6 Apr 2016
5CD3	Structure of immature VRC01-class antibody DRVIA7 Homo sapiens	Marc is an author on the primary citation	X-ray	2.90 Å	6 Apr 2016
5C7K	Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195 Homo sapiens; Human immunodeficiency virus 1	Marc is an author on the primary citation	X-ray	4.60 Å	7 Oct 2015
4RBO	Crystal structure of a Nanog homeobox (NANOG) from Homo sapiens at 3.30 A resolution Homo sapiens	Marc is an author on the primary citation	X-ray	3.30 Å	1 Oct 2014
4NCO	Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 Homo sapiens; Human immunodeficiency virus 1	Marc is an author on the primary citation	X-ray	4.70 Å	13 Nov 2013
4JM4	Crystal Structure of PGT 135 Fab Homo sapiens	Marc is an author on the primary citation	X-ray	1.75 Å	29 May 2013
4JM2	Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab Homo sapiens; Human immunodeficiency virus 1	Marc is an author on the primary citation	X-ray	3.10 Å	29 May 2013
4G6A	Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33 Homo sapiens; Orthohepacivirus hominis	Marc is an author on the primary citation	X-ray	2.50 Å	26 Sep 2012
3O0F	Crystal structure of a putative metal-dependent phosphoesterase (BAD_1165) from bifidobacterium adolescentis atcc 15703 at 1.94 A resolution Bifidobacterium adolescentis ATCC 15703	Marc is an author on the primary citation	X-ray	1.94 Å	25 Aug 2010
3NL9	Crystal structure of a putative NTP pyrophosphohydrolase (Exig_1061) from EXIGUOBACTERIUM SP. 255-15 at 1.78 A resolution Exiguobacterium artemiae 255-15	Marc is an author on the primary citation	X-ray	1.78 Å	21 Jul 2010
3M82	Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.40 A resolution (PMSF inhibitor complex structure) Thermotoga maritima	Marc is an author on the primary citation	X-ray	2.40 Å	26 May 2010
3M83	Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.12 A resolution (paraoxon inhibitor complex structure) Thermotoga maritima	Marc is an author on the primary citation	X-ray	2.12 Å	12 May 2010
3M81	Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.50 A resolution (native apo structure) Thermotoga maritima	Marc is an author on the primary citation	X-ray	2.50 Å	21 Apr 2010
3L4B	Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima Thermotoga maritima MSB8	Deposited by Marc and an author on the primary citation	X-ray	3.45 Å	16 Feb 2010
3L5O	Crystal structure of protein with unknown function from DUF364 family (ZP_00559375.1) from Desulfitobacterium hafniense DCB-2 at 2.01 A resolution Desulfitobacterium hafniense DCB-2	Marc is an author on the primary citation	X-ray	2.01 Å	2 Feb 2010
3K5J	Crystal structure of Putative SUFU (suppressor of fused protein) homolog (YP_208451.1) from Neisseria gonorrhoeae FA 1090 at 1.40 A resolution Neisseria gonorrhoeae FA 1090	Marc is an author on the primary citation	X-ray	1.40 Å	26 Jan 2010
3KK7	Crystal structure of Putative cell invasion protein with MAC/Perforin domain (NP_812351.1) from BACTERIODES THETAIOTAOMICRON VPI-5482 at 2.46 A resolution Bacteroides thetaiotaomicron VPI-5482	Marc is an author on the primary citation	X-ray	2.46 Å	24 Nov 2009
3JXO	Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima Thermotoga sp. RQ2	Deposited by Marc and an author on the primary citation	X-ray	1.55 Å	6 Oct 2009
3IRB	Crystal structure of protein with unknown function from DUF35 family (13815350) from SULFOLOBUS SOLFATARICUS at 1.80 A resolution Saccharolobus solfataricus	Marc is an author on the primary citation	X-ray	1.80 Å	1 Sep 2009
3HSA	Crystal structure of pleckstrin homology domain (YP_926556.1) from SHEWANELLA AMAZONENSIS SB2B at 1.99 A resolution Shewanella amazonensis SB2B	Marc is an author on the primary citation	X-ray	1.99 Å	23 Jun 2009
3HBZ	Crystal structure of a putative glycoside hydrolase (bt_2081) from bacteroides thetaiotaomicron vpi-5482 at 2.05 A resolution Bacteroides thetaiotaomicron VPI-5482	Marc is an author on the primary citation	X-ray	2.05 Å	26 May 2009
3H50	CRYSTAL STRUCTURE OF A TETRACENOMYCIN POLYKETIDE SYNTHESIS PROTEIN (TCMJ) FROM XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS AT 1.60 A RESOLUTION Xanthomonas campestris pv. campestris	Marc is an author on the primary citation	X-ray	1.60 Å	5 May 2009
3H41	CRYSTAL STRUCTURE OF A NLPC/P60 FAMILY PROTEIN (BCE_2878) FROM BACILLUS CEREUS ATCC 10987 AT 1.79 A RESOLUTION Bacillus cereus ATCC 10987	Marc is an author on the primary citation	X-ray	1.79 Å	5 May 2009
3H0N	Crystal structure of a duf1470 family protein (jann_2411) from jannaschia sp. ccs1 at 1.45 A resolution Jannaschia sp. CCS1	Marc is an author on the primary citation	X-ray	1.45 Å	21 Apr 2009
3GF8	Crystal structure of putative polysaccharide binding proteins (DUF1812) (NP_809975.1) from BACTEROIDES THETAIOTAOMICRON VPI-5482 at 2.20 A resolution Bacteroides thetaiotaomicron VPI-5482	Marc is an author on the primary citation	X-ray	2.20 Å	24 Mar 2009
3F1Z	Crystal structure of putative nucleic acid-binding lipoprotein (YP_001337197.1) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 2.46 A resolution Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Marc is an author on the primary citation	X-ray	2.46 Å	18 Nov 2008
3EQX	CRYSTAL STRUCTURE OF A FIC FAMILY PROTEIN (SO_4266) FROM SHEWANELLA ONEIDENSIS AT 1.6 A RESOLUTION Shewanella oneidensis	Marc is an author on the primary citation	X-ray	1.60 Å	14 Oct 2008
3E0F	Crystal structure of a putative metal-dependent phosphoesterase (bad_1165) from bifidobacterium adolescentis atcc 15703 at 2.40 A resolution Bifidobacterium adolescentis ATCC 15703	Marc is an author on the primary citation	X-ray	2.40 Å	2 Sep 2008
3DUE	CRYSTAL STRUCTURE OF A PUTATIVE PERIPLASMIC PROTEIN FROM DUF2874 FAMILY (BVU_2987) FROM BACTEROIDES VULGATUS ATCC 8482 AT 1.85 A RESOLUTION Phocaeicola vulgatus ATCC 8482	Marc is an author on the primary citation	X-ray	1.85 Å	5 Aug 2008
3DEE	CRYSTAL STRUCTURE OF A PUTATIVE REGULATORY PROTEIN INVOLVED IN TRANSCRIPTION (NGO1945) FROM NEISSERIA GONORRHOEAE FA 1090 AT 2.25 A RESOLUTION Neisseria gonorrhoeae FA 1090	Marc is an author on the primary citation	X-ray	2.10 Å	5 Aug 2008
3DCX	Crystal structure of a duf1696 family protein with a pleckstrin-homology domain (shew_0819) from shewanella loihica pv-4 at 2.00 A resolution Shewanella loihica PV-4	Marc is an author on the primary citation	X-ray	2.00 Å	29 Jul 2008
3D00	Crystal structure of a tungsten formylmethanofuran dehydrogenase subunit e (fmde)-like protein (syn_00638) from syntrophus aciditrophicus at 1.90 A resolution Syntrophus aciditrophicus SB	Marc is an author on the primary citation	X-ray	1.90 Å	20 May 2008
3CM1	Crystal structure of SsgA-like sporulation-specific cell division protein (YP_290167.1) from Thermobifida fusca YX-ER1 at 2.60 A resolution Thermobifida fusca YX	Marc is an author on the primary citation	X-ray	2.60 Å	1 Apr 2008
3CGH	Crystal structure of a susd homolog (bt_3984) from bacteroides thetaiotaomicron vpi-5482 at 1.70 A resolution Bacteroides thetaiotaomicron VPI-5482	Marc is an author on the primary citation	X-ray	1.70 Å	18 Mar 2008
3BYQ	Crystal structure of a duf1185 family protein (bb2672) from bordetella bronchiseptica rb50 at 1.70 A resolution Bordetella bronchiseptica RB50	Marc is an author on the primary citation	X-ray	1.70 Å	29 Jan 2008
3BY7	CRYSTAL STRUCTURE OF A PROTEIN STRUCTURALLY SIMILAR TO SM/LSM-LIKE RNA-BINDING PROTEINS (JCVI_PEP_1096686650277) FROM UNCULTURED MARINE ORGANISM AT 2.60 A RESOLUTION uncultured marine organism	Marc is an author on the primary citation	X-ray	2.60 Å	29 Jan 2008
3BOS	Crystal structure of a putative dna replication regulator HDA (SAMA_1916) from Shewanella amazonensis sb2b at 1.75 A resolution Shewanella amazonensis SB2B	Marc is an author on the primary citation	X-ray	1.75 Å	15 Jan 2008
3B77	Crystal structure of a ph domain containing bacterial protein (exig_2160) from exiguobacterium sibiricum 255-15 at 2.42 A resolution Exiguobacterium artemiae 255-15	Marc is an author on the primary citation	X-ray	2.42 Å	13 Nov 2007
2RA9	Crystal structure of a duf1285 family protein (sbal_2486) from shewanella baltica os155 at 1.40 A resolution Shewanella baltica OS155	Marc is an author on the primary citation	X-ray	1.40 Å	16 Oct 2007
2RE3	CRYSTAL STRUCTURE OF a DUF1285 family protein (SPO_0140) FROM SILICIBACTER POMEROYI DSS-3 AT 2.50 A RESOLUTION Ruegeria pomeroyi DSS-3	Marc is an author on the primary citation	X-ray	2.50 Å	9 Oct 2007
2QTP	Crystal structure of a duf1185 family protein (spo0826) from silicibacter pomeroyi dss-3 at 2.10 A resolution Ruegeria pomeroyi DSS-3	Marc is an author on the primary citation	X-ray	2.10 Å	21 Aug 2007
2Q8U	CRYSTAL STRUCTURE OF MRE11 FROM THERMOTOGA MARITIMA MSB8 (TM1635) AT 2.20 A RESOLUTION Thermotoga maritima MSB8	Marc is an author on the primary citation	X-ray	2.20 Å	26 Jun 2007
2Q3L	CRYSTAL STRUCTURE OF AN UNCHARACTERIZED PROTEIN FROM DUF3478 FAMILY WITH A SPOIIAA-LIKE FOLD (SHEW_3102) FROM SHEWANELLA LOIHICA PV-4 AT 2.25 A RESOLUTION Shewanella loihica PV-4	Marc is an author on the primary citation	X-ray	2.25 Å	12 Jun 2007
2PV7	Crystal structure of chorismate mutase / prephenate dehydrogenase (tyrA) (1574749) from Haemophilus influenzae RD at 2.00 A resolution Haemophilus influenzae	Marc is an author on the primary citation	X-ray	2.00 Å	22 May 2007
2OOK	Crystal structure of a protein with unknown function (YP_749275.1) from Shewanella Frigidimarina NCIMB 400 at 1.80 A resolution Shewanella frigidimarina NCIMB 400	Marc is an author on the primary citation	X-ray	1.80 Å	6 Feb 2007
2OOC	Crystal structure of Histidine Phosphotransferase ShpA (NP_419930.1) from Caulobacter crescentus at 1.52 A resolution Caulobacter vibrioides CB15	Marc is an author on the primary citation	X-ray	1.52 Å	6 Feb 2007
2IIZ	Crystal structure of putative melanin biosynthesis protein TyrA with bound heme (NP_716371.1) from Shewanella Oneidensis at 2.30 A resolution Shewanella oneidensis	Marc is an author on the primary citation	X-ray	2.30 Å	14 Nov 2006
2IAY	Crystal structure of a duf1831 family protein (lp2179) from lactobacillus plantarum at 1.20 A resolution Lactiplantibacillus plantarum	Marc is an author on the primary citation	X-ray	1.20 Å	10 Oct 2006
2ICH	CRYSTAL STRUCTURE OF A PUTATIVE ATTH (NE1406) FROM NITROSOMONAS EUROPAEA AT 2.00 A RESOLUTION Nitrosomonas europaea	Marc is an author on the primary citation	X-ray	2.00 Å	3 Oct 2006
2HUJ	Crystal structure of a protein of uknown function (NP_471338.1) from Listeria innocua at 1.74 A resolution Listeria innocua	Marc is an author on the primary citation	X-ray	1.74 Å	8 Aug 2006
2HBW	Crystal structure of a putative endopeptidase (ava_3396) from anabaena variabilis atcc 29413 at 1.05 A resolution Trichormus variabilis ATCC 29413	Marc is an author on the primary citation	X-ray	1.05 Å	8 Aug 2006
2HAG	Crystal structure of a putative dyp-type peroxidase protein (so_0740) from shewanella oneidensis at 2.75 A resolution Shewanella oneidensis	Marc is an author on the primary citation	X-ray	2.75 Å	8 Aug 2006
2GVI	Crystal structure of a putative formylmethanofuran dehydrogenase subunit e (ta1109) from thermoplasma acidophilum at 1.87 A resolution Thermoplasma acidophilum	Marc is an author on the primary citation	X-ray	1.87 Å	13 Jun 2006
2H1T	Crystal structure of a duf1089 family protein (pa1994) from pseudomonas aeruginosa at 1.80 A resolution Pseudomonas aeruginosa	Marc is an author on the primary citation	X-ray	1.80 Å	30 May 2006
2GVK	Crystal structure of a dye-decolorizing peroxidase (DyP) from Bacteroides thetaiotaomicron VPI-5482 at 1.6 A resolution Bacteroides thetaiotaomicron VPI-5482	Marc is an author on the primary citation	X-ray	1.60 Å	16 May 2006
2GLZ	Crystal structure of a formylmethanofuran dehydrogenase subunit e-like protein (dhaf_2992) from desulfitobacterium hafniense dcb-2 at 1.45 A resolution Desulfitobacterium hafniense DCB-2	Marc is an author on the primary citation	X-ray	1.45 Å	18 Apr 2006
2GHR	Crystal structure of homoserine o-succinyltransferase (NP_981826.1) from Bacillus cereus ATCC 10987 at 2.40 A resolution Bacillus cereus	Marc is an author on the primary citation	X-ray	2.40 Å	11 Apr 2006
2FG0	Crystal structure of a putative gamma-d-glutamyl-l-diamino acid endopeptidase (npun_r0659) from nostoc punctiforme pcc 73102 at 1.79 A resolution Nostoc punctiforme PCC 73102	Marc is an author on the primary citation	X-ray	1.79 Å	10 Jan 2006
2EVR	CRYSTAL STRUCTURE OF A PUTATIVE GAMMA-D-GLUTAMYL-L-DIAMINO ACID ENDOPEPTIDASE (NPUN_R0659) FROM NOSTOC PUNCTIFORME PCC 73102 AT 1.60 A RESOLUTION Nostoc punctiforme PCC 73102	Marc is an author on the primary citation	X-ray	1.60 Å	22 Nov 2005
2ETS	CRYSTAL STRUCTURE OF A BACTERIAL DOMAIN OF UNKNOWN FUNCTION FROM DUF1798 FAMILY (MW1337) FROM STAPHYLOCOCCUS AUREUS SUBSP. AUREUS AT 2.25 A RESOLUTION Staphylococcus aureus subsp. aureus MW2	Marc is an author on the primary citation	X-ray	2.25 Å	8 Nov 2005
1VLQ	Crystal structure of Acetyl xylan esterase (TM0077) from Thermotoga maritima at 2.10 A resolution Thermotoga maritima MSB8	Marc is an author on the primary citation	X-ray	2.10 Å	24 Aug 2004
1EVS	CRYSTAL STRUCTURE OF HUMAN ONCOSTATIN M Homo sapiens	Deposited by Marc and an author on the primary citation	X-ray	2.20 Å	13 Sep 2000

Reference structures

RCSB data only, for comparison

Entry	Title	Method	Resolution	Released
1IEP	CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.	X-ray	2.10 Å	18 Apr 2001
6O0K	crystal structure of BCL-2 with venetoclax	X-ray	1.62 Å	22 May 2019
6OIM	Crystal Structure of human KRAS G12C covalently bound to AMG 510	X-ray	1.65 Å	6 Nov 2019
9E5D	Discovery of an Orally Biovailable KRAS G12D Inhibitor	X-ray	1.36 Å	22 Jan 2025

Try it

mdeller.com DEBRIS ↗ every DOI-verified paper on micro and nanoplastics in human disease, read by a fine-tuned 3B model and mapped by polymer, tissue, mechanism … mdeller.com BINMAN ↗ an atlas of the molecular glues already sitting in the PDB: every ligand that buries surface against two protein chains at once, found by ge… mdeller.com NOBBLE ↗ whether a molecular glue actually creates the interface it is credited with: every predicted ternary complex scored against 285,996 experime… mdeller.com PODIUM ↗ an interview deck in one live Mol* viewer: four selectivity campaigns, every contact measured by PLIP in the deposited structure, KLIFS and … mdeller.com GATECRASHER ↗ four published drug discovery campaigns in one shell: the pocket, the SAR, every designed edit, and the structural basis of selectivity mdeller.com PANTS ↗ PETase ANnotation and Triage System: mines metagenomic sequence space for PET-degrading enzymes that work at 37 °C in serum rather than at 7…