10PJ: JAK2 kinase (JH1 domain) in complex with povorcitinib
X-ray · 1.59 Å · released 10 Jun 2026 · Homo sapiens
Ligands: MLA, A1C68
How it was solved
- Method
- X-ray
- Resolution
- 1.59 Å
- Released
- 10 Jun 2026
- Rfree
- 0.231
- Rwork
- 0.201
- Clashscore
- 5.35
- Ramachandran outliers
- 0.00%
- Rotamer outliers
- 0.18%
Crystallisation
- Technique
- Vapor Diffusion, Sitting Drop
- Temperature
- 293.0 K
100 mM MD - Buffer System 6 pH 8.0, 1.4 M Na2-Malonate pH 6.0
What it led to
2026 – Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases
Casebook · 2 Jun 2026
Primary citation
Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases
Journal of Medicinal Chemistry 2026
JAK2 is the target of 12 approved drugs in ChEMBL.
Do it yourself
Field Guide: Xray and crystallisation
Unlocking Membrane Protein Structures: The Crystallization Revolution Reshaping Drug Discovery
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization
AXIS: Closing the Loop on Crystal Detection
Playbook
The Self-Driving Lab: How Automation and AI Are Redefining the Pace of Discovery
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