8UV0: Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
X-ray · 1.55 Å · released 14 Feb 2024 · Homo sapiens
Related entries for the same target
same UniProt accessionLigand: XKU
How it was solved
- Method
- X-ray
- Resolution
- 1.55 Å
- Released
- 14 Feb 2024
- Rfree
- 0.203
- Rwork
- 0.155
- Clashscore
- 1.18
- Ramachandran outliers
- 0.00%
- Rotamer outliers
- 0.46%
Crystallisation
- Technique
- Vapor Diffusion, Sitting Drop
- pH
- 8.5
- Temperature
- 293.0 K
0.1 M Tris pH 8.5, 16% PEG 2000 MME, 0.2 M trimethylamine N-oxide
What it led to
2024 – Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective CDK2 Inhibitors
Casebook · 11 Aug 2025
Do it yourself
Field Guide: Xray and crystallisation
Unlocking Membrane Protein Structures: The Crystallization Revolution Reshaping Drug Discovery
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization
AXIS: Closing the Loop on Crystal Detection
Playbook
The Self-Driving Lab: How Automation and AI Are Redefining the Pace of Discovery
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