Description: This HIV-1 Env trimer structure in complex with two broadly neutralizing antibodies—PGT128 and 8ANC195—reveals complete epitopes on the native-like trimer for the first time. The structure uncovers the full 8ANC195 interface spanning gp120 and gp41, and demonstrates how PGT128 allosterically repositions the N262 glycan, providing direct blueprints for structure-based HIV vaccine design.