Crystal Structure of an Immature VRC01-Class Antibody DRVIA7 from a Chinese Donor Bound to Clade A/E HIV-1 gp120 Core
Crystal Structure of an Immature VRC01-Class Antibody DRVIA7 from a Chinese Donor Bound to Clade A/E HIV-1 gp120 Core
Description: This structure captures an immature VRC01-class antibody (DRVIA7) in complex with HIV-1 gp120, revealing how key glycans—particularly at positions N276 and V5—create steric roadblocks that impede the maturation of broadly neutralizing antibodies. The structural and longitudinal analyses inform glycan-accommodating vaccine design strategies for eliciting VRC01-class responses across diverse populations.