6OIM: Crystal Structure of human KRAS G12C covalently bound to AMG 510
X-ray · 1.65 Å · released 6 Nov 2019 · Homo sapiens
Ligands: GDP, MOV
How it was solved
- Method
- X-ray
- Resolution
- 1.65 Å
- Released
- 6 Nov 2019
- Rfree
- 0.215
- Rwork
- 0.181
- Clashscore
- 1.46
- Ramachandran outliers
- 0.00%
- Rotamer outliers
- 0.00%
Crystallisation
- Technique
- Vapor Diffusion, Sitting Drop
- pH
- 6.5
- Temperature
- 293.0 K
1mM MgCl2, 0.1M MES pH6.5, 30% PEG4000
What it led to
No case written yet for this entry.
Primary citation
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature 2019
KRAS is the target of 2 approved drugs in ChEMBL.
Do it yourself
Field Guide: Xray and crystallisation
Unlocking Membrane Protein Structures: The Crystallization Revolution Reshaping Drug Discovery
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization
AXIS: Closing the Loop on Crystal Detection
Playbook
The Self-Driving Lab: How Automation and AI Are Redefining the Pace of Discovery
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