4JM2: Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab
X-ray · 3.10 Å · released 29 May 2013 · Homo sapiens; Human immunodeficiency virus 1
Ligand: NAG
How it was solved
- Method
- X-ray
- Resolution
- 3.10 Å
- Released
- 29 May 2013
- Rfree
- 0.285
- Rwork
- 0.238
- Clashscore
- 33.99
- Ramachandran outliers
- 0.52%
- Rotamer outliers
- 3.93%
Crystallisation
- Technique
- Vapor Diffusion, Sitting Drop
- pH
- 7.0
- Temperature
- 293.0 K
20% PEG2000, 0.1 M Tris, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
What it led to
No case written yet for this entry.
Primary citation
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
Nature Structural and Molecular Biology 2013
Do it yourself
Field Guide: Xray and crystallisation
Unlocking Membrane Protein Structures: The Crystallization Revolution Reshaping Drug Discovery
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization
AXIS: Closing the Loop on Crystal Detection
Playbook
The Self-Driving Lab: How Automation and AI Are Redefining the Pace of Discovery
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