6O0K: crystal structure of BCL-2 with venetoclax
X-ray · 1.62 Å · released 22 May 2019 · Homo sapiens
Ligand: LBM
How it was solved
- Method
- X-ray
- Resolution
- 1.62 Å
- Released
- 22 May 2019
- Rfree
- 0.202
- Rwork
- 0.161
- Clashscore
- 6.06
- Ramachandran outliers
- 0.00%
- Rotamer outliers
- 0.00%
Crystallisation
- Technique
- Vapor Diffusion
- pH
- 6.0
- Temperature
- 291.0 K
5% PEG4K, 40%PEG400, 0.1M MES pH 6.0
What is new
What it led to
No case written yet for this entry.
Primary citation
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun 2019
BCL2 is the target of 1 approved drug in ChEMBL.
Do it yourself
Field Guide: Xray and crystallisation
Unlocking Membrane Protein Structures: The Crystallization Revolution Reshaping Drug Discovery
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization
AXIS: Closing the Loop on Crystal Detection
Playbook
The Self-Driving Lab: How Automation and AI Are Redefining the Pace of Discovery
Tools
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