9BA0: Structural mechanism of CB1R binding to peripheral and biased inverse agonists
Cryo-EM · 3.13 Å · released 20 Nov 2024 · Homo sapiens; Lama glama; Pyrococcus abyssi GE5
Ligand: A1AKN
How it was solved
- Method
- EM
- Resolution
- 3.13 Å
- Released
- 20 Nov 2024
- Clashscore
- 6.31
- Ramachandran outliers
- 0.00%
- Rotamer outliers
- 0.00%
What is new
What it led to
Compositional Protein Design: Building Proteins from 3D Ellipsoid Blueprints
Field Guide · 11 Aug 2025
Primary citation
Structural mechanism of CB 1 R binding to peripheral and biased inverse agonists.
Nat Commun 2024
CNR1 is the target of 4 approved drugs in ChEMBL.
Do it yourself
Field Guide: Cryo em
Outrunning Diffusion: The Fast Lane in CryoEM Grid Preparation
Revolutionary Cryo-EM Breakthrough: Di-Gembodies Transform Small Protein Structure Determination
Playbook
The Self-Driving Lab: How Automation and AI Are Redefining the Pace of Discovery
Tools
GOBSMACKED ↗
fold, dock, relax and annotate a protein-ligand complex on your own GPU, then find the crystal structure and g
CODSWALLOP ↗
every PDB entry for a protein family in one place: what was actually made, what it bound, what crystallised, a
TopPDBLX ↗
every crystallisation condition in the protein data bank, parsed and indexed: what worked, how often, and how
FlexAppeal ↗
Set up protein molecular dynamics without writing the script: every OpenMM option explained, a self-contained
BoltzMaker ↗
Build and analyze Boltz-2 protein structure prediction campaigns: a guided input wizard, YAML generation, and