3SN6: Crystal structure of the beta2 adrenergic receptor-Gs protein complex
X-ray · 3.20 Å · released 20 Jul 2011 · Bos taurus; Homo sapiens; Lama glama; Rattus norvegicus; Tequatrovirus T4
Ligand: P0G
How it was solved
- Method
- X-ray
- Resolution
- 3.20 Å
- Released
- 20 Jul 2011
- Rfree
- 0.277
- Rwork
- 0.226
- Clashscore
- 22.65
- Ramachandran outliers
- 0.08%
- Rotamer outliers
- 1.66%
Crystallisation
- Technique
- Lipidic Cubic Phase
- pH
- 6.5
- Temperature
- 293.0 K
350-450 mM potassium nitrate, 100 mM MES, 1 mM TCEP, 10 mM phosphonoformate, 0.01 mM BI167107, 18-22% PEG400. Crystals were grown in a 10:1 (w:w) MAG 7.7:cholesterol lipid mix. , pH 6.5, Lipidic cubic phase, temperature 293K
What is new
What it led to
GOBSMACKED: fold, dock, relax and annotate a protein-ligand complex, then grade it against the real crystal structure
Playbook · 15 Sep 2026
Do it yourself
Field Guide: Xray and crystallisation
Unlocking Membrane Protein Structures: The Crystallization Revolution Reshaping Drug Discovery
Engineering Protein Stability: Unlocking the Secrets of Successful Crystallization
AXIS: Closing the Loop on Crystal Detection
Playbook
The Self-Driving Lab: How Automation and AI Are Redefining the Pace of Discovery
Tools
GOBSMACKED ↗
fold, dock, relax and annotate a protein-ligand complex on your own GPU, then find the crystal structure and g
CODSWALLOP ↗
every PDB entry for a protein family in one place: what was actually made, what it bound, what crystallised, a
TopPDBLX ↗
every crystallisation condition in the protein data bank, parsed and indexed: what worked, how often, and how
FlexAppeal ↗
Set up protein molecular dynamics without writing the script: every OpenMM option explained, a self-contained
BoltzMaker ↗
Build and analyze Boltz-2 protein structure prediction campaigns: a guided input wizard, YAML generation, and